nags N-acetylglutamate synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nagsprovided by ZNC
Official Full Name: N-acetylglutamate synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-121219-2
See related: Ensembl:ENSDARG00000077193 AllianceGenome:ZFIN:ZDB-GENE-121219-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables acetyl-CoA:L-glutamate N-acetyltransferase activity and arginine binding activity. Predicted to be involved in arginine biosynthetic process. Predicted to act upstream of or within urea cycle. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (23030030..23043478)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (22899448..22912884)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that under physiological conditions N-acetylglutamate synthase (NAGS) catalyzes formation of N-acetylglutamate at the maximal rate.
Title: Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA:L-glutamate N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA:L-glutamate N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA:L-glutamate N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables arginine binding	IDA Inferred from Direct Assay more info	PubMed
enables methione N-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylglutamate synthase, mitochondrial

XP_021327092.1

EC 2.3.1.1

XP_021327093.1

EC 2.3.1.1

XP_021329189.1

EC 2.3.1.1

XP_685919.3

EC 2.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423779.1 → NP_001410708.1 N-acetylglutamate synthase, mitochondrial

Status: VALIDATED

Source sequence(s)

AL935200

UniProtKB/TrEMBL

A0A8M9PWK2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

23030030..23043478

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473514.1 → XP_021329189.1 N-acetylglutamate synthase, mitochondrial isoform X2

Related

ENSDARP00000154041.1, ENSDART00000187900.1

Conserved Domains (2) summary

pfam04768
Location:341 → 500

NAT; N-acetyltransferase, of N-acetylglutamate synthase

cl00452
Location:84 → 355

AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...
XM_680827.9 → XP_685919.3 N-acetylglutamate synthase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

E7FCP8

UniProtKB/TrEMBL

A0A8M9PJE2

Related

ENSDARP00000101563.2, ENSDART00000110343.4

Conserved Domains (2) summary

pfam04768
Location:342 → 501

NAT; NAT, N-acetyltransferase, of N-acetylglutamate synthase

cl00452
Location:84 → 356

AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394530.1 Reference GRCz11 ALT_DRER_TU_1

Range

99632..113065

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471418.1 → XP_021327093.1 N-acetylglutamate synthase, mitochondrial isoform X2

Conserved Domains (2) summary

pfam04768
Location:341 → 500

NAT; N-acetyltransferase, of N-acetylglutamate synthase

cl00452
Location:84 → 355

AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...
XM_021471417.1 → XP_021327092.1 N-acetylglutamate synthase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M9P8E6, A0A8M9PJE2

Conserved Domains (2) summary

pfam04768
Location:342 → 501

NAT; N-acetyltransferase, of N-acetylglutamate synthase

cl00452
Location:84 → 356

AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...